Akt as a mediator of cell death

Akt as a mediator of cell death.

Protein kinase B/Akt possesses prosurvival and antiapoptotic activities and is involved in growth factor-mediated neuronal protection. In this study we establish Akt deactivation as a causal mediator of cell death. Akt deactivation occurs in multiple models of cell death including N-methyl-d-aspartate excitotoxicity, vascular stroke, and nitric oxide (NO)- and hydrogen peroxide (H2O2)-elicited ...

Akt as a Mediator of Secretory Phospholipase

Pannexin1 as mediator of inflammation and cell death.

Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their extracellular environment. By doing so, pannexin signaling dictates several physiological functions, but equally underlies a number of pathological processes. Indeed, pannexin channels drive inflammation by assisting in the activation of inflammasom...

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when cou...

Relationship of Attachment Styles to God and Depression with Death Anxiety as a Mediator among Women with Breast Cancer

Background and Purpose: Breast cancer, which accounts for a high mortality rate due to cancer, is the most common cancer in females. Since this disease has negative effects on life, it can lead to depression. Therefore, this study aimed to investigate the relationship of attachment styles to God and depression in females suffering from breast cancer with death anxiety as a mediator. Materials ...